Pulmonary Irritation After Inhalation Exposure to Benzalkonium Chloride in Rats
نویسندگان
چکیده
منابع مشابه
Pulmonary irritation after inhalation exposure to benzalkonium chloride in rats.
BACKGROUND Benzalkonium chloride (BAC) is a quaternary ammonium compound (QAC) with a C8 to C18 chain length of alkyl groups. Since BAC exerts toxic effects on microorganisms, it has been used as an effective germicide and preservative, mostly in cosmetic industry and medicine. However, the toxic potential of BAC may be hazardous to humans, due to the common use of preparations containing BAC a...
متن کاملToxic effect in the lungs of rats after inhalation exposure to benzalkonium chloride.
BACKGROUND Benzalkonium chloride (BAC) is a quaternary ammonium compound (QAC) toxic to microorganisms. Inhalation is one of the major possible routes of human exposure to BAC. MATERIALS AND METHODS Experiments were performed on female Wistar rats. The rats were exposed to aerosol of BAC water solution at the target concentration of 0 (control group) and 35 mg/m(3) for 5 days (6 h/day) and, a...
متن کاملCatecholamine levels in the brain of rats exposed by inhalation to benzalkonium chloride.
OBJECTIVES The aim of the study was to obtain quantitative data on the effect of inhalation exposure to benzalkonium chloride (BAC) on the concentration of catecholamines and their metabolites in selected brain structures. Additionally, concentration of corticosterone (CORT) in plasma was estimated. MATERIAL AND METHODS Wistar rats were subjected to a single (6-hour) or repeated (3 days, 6 h/...
متن کاملRepeated exposure to benzalkonium chloride in the Ex Vivo Eye Irritation Test (EVEIT): observation of isolated corneal damage and healing.
The prediction of side-effects is a key issue in the REACH initiative on chemicals, in the production of cosmetics and in the preclinical testing of drugs. A new ex vivo test for repeated substance application is presented, that is able to identify corrosive and irritant effects on the eye by using crucial endpoints, such as cellular and morphological damage, and healing characteristics. The te...
متن کاملActinides behaviour after inhalation exposure of rats to industrial NpO2
Neptunium-237 is a long-live emitters formed after americium-241 decay which is mainly produced after irradiation of nuclear fuels. NpO2 can be produced after irradiated fuel reprocessing. Without any experimental results on this chemical form after inhalation, the ICRP considered NpO2 as a type M compound. Preliminary results suggested that after inhalation exposure of rats to NpO2 the biologi...
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ژورنال
عنوان ژورنال: International Journal of Occupational Medicine and Environmental Health
سال: 2008
ISSN: 1896-494X,1232-1087
DOI: 10.2478/v10001-008-0020-1